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The gene associated with sickle cell anemia is HBB, which is located in region 15.5 on the short arm of chromosome 11. There are many variations that can cause sickle cell, but primarily it is caused by the hemoglobin variant Hb S. According to the human genome project website: "the hydrophobic amino acid valine takes the place of hydrophilic glutamic acid at the sixth amino acid position of the HBB polypeptide chain. This substitution creates a hydrophobic spot on the outside of the protein structure that sticks to the hydrophobic region of an adjacent hemoglobin molecule's beta chain. This clumping together (polymerization) of Hb S molecules into rigid fibers causes the "sickling" of red blood cells." In a nutshell, when the hydrophobic (water fearing) amino replaces a hydrophilic one (water loving) on the protein chain, it creates a spot that sticks to another similar mutated gene, and they clump together, creating a sickle shaped cell. Looking at the location and incidence rates of sickle cell amenia, scientists believe that because malaria rates are high in the region, the body has created this defense against the disease -- an evolutionary self defense. Hope that helps :-)
Wiki User
∙ 15y ago
Wiki User
∙ 9y agoIt just can. Even this tiny one base change can cause a mutation that is this severe. Many do not, but this one does.
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What type of anemia does a gene mutation cause?
A certain substitution in human DNA changes the code for hemoglobin; this ultimately results in sickle-cell anima.
What happens when a person has sickle cell anemia?
sickle cell anemia is releated with RBC . RBC will change in size ( microcytic ) and shap will change (sickling shap) that are cause in blokers vascular > then cause hypoxia in some organes that is cause tachycardia and shortness breath some time palor
What can cause a attack of sickle cell anemia?
Although sickle cell anemia(SS) and sickle cell disease(SC) are considered genetic mutations, I believe the question is...What are possible causes for a sickle cell attack? Anything that causes a constriction of the blood vessels would seem to be a cause. Smoking, coffee, and alcohol to name a few. Dehydration also appears to play a big role.
The cause of sickle cell anemia is?
a child must inherit two copies of the defective gene in order to have a cystics fibrosis but when it come to sickle-cell anemia it is a disease passed down through families in which red blood cells from an abnormal sickle or crescent shape.Red blood cells carry oxygen to the body and are normally shaped like a disc so what causes sickle-cell anemia is the two copies that they get from both parents which gets passed down through families.
What is sickle cell Trait The condition is Autosomal and there is Codominance between alleles what does this mean?
sickle cell trait is inherited from one set of gene alleles from both parents. if you get two traits together it will cause sickle cell anemia which is a disease, sickle cell trait is not a disease. i dont know what autosomal means!! i dont know what codominance means!!
Do enzymes cause sickle cell anemia?
No.
What can cause sickle cell anemia?
Genetics
Can Sickle's Cell Anemia cause positive drug tests results?
No, drug test look for specific chemicals.
Can sickle cell anemia cause pneumonia?
no it dose not sickle cell anemia causes death only if African Americans
What type of mutation cause cell anemia?
Mutations in the hemoglobin molecules cause sickle cell anemia.
Can sickle cell anemia cause sterility?
yes
What disorder does a mutation in hemoglobin cause?
Sickle cell anemia.
What disorder does mutation in the hemoglobin cause?
Sickle cell anemia.
What type of anemia does a gene mutation cause?
A certain substitution in human DNA changes the code for hemoglobin; this ultimately results in sickle-cell anima.
Can sickle cell anemia cause chronic kidney failure?
Yes
What happens when a person has sickle cell anemia?
sickle cell anemia is releated with RBC . RBC will change in size ( microcytic ) and shap will change (sickling shap) that are cause in blokers vascular > then cause hypoxia in some organes that is cause tachycardia and shortness breath some time palor
What can cause a attack of sickle cell anemia?
Although sickle cell anemia(SS) and sickle cell disease(SC) are considered genetic mutations, I believe the question is...What are possible causes for a sickle cell attack? Anything that causes a constriction of the blood vessels would seem to be a cause. Smoking, coffee, and alcohol to name a few. Dehydration also appears to play a big role.
