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Q: What structure separates the two major lobes of the liver?
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What structure is abundant in liver cells?

Macro anatomy of liverFor the ease of understanding , liver is anatomically divided into lobes. On its top view, liver shows the left and right lobes separated by the falciform ligament. On the inferior view (from below), it appears with four lobes. However, the organ is roughly divided into 2 principal lobes, right and a left lobe. The falciform ligament forms a septum resulting in the left and right lobes. The abdomen and the liver is thinly separated by a membrane called peritoneum. Peritoneum is the covering layer of all the abdominal organs. Peritoneum has 2 divisions; outer parietal divisions and the inner visceral layer that actually touches the surface of liver. Liver is surrounded by a number of organs forming various impressions. Some of the impressions are gastric impression, renal impression, suprarenal impression, colic impression, and duodenal impression.Microscopic anatomy of liverUnlike other organs, the liver is supplied with two major sources of blood; the portal channel and the hepatic channel. The hepatic artery connected to the major abdominal aorta brings pure blood from the heart, similarly, the impure blood is removed from the liver with the help of 3 hepatic veins. Additionally, portal circulation rich in multiple capillaries and veins also supply the blood from in and out of the liver. Microscopically, liver is divided into a number of hepatic lobules. Each lobule appears hexagonal made up of plates of hepatocytes. Hepatocytes (liver cells) joins the central vein that carry blood out of the liver. If we analyse the histology (microscopic anatomy) of the liver, two major types of liver cells are found: parenchymal cells and the non-parenchymal cells. 3/4th of the liver is filled with the parenchymal hepatocytes and the remaining ¼ is made up of non-parenchymal cells. The liver contains sinusoids, lined with 2 types of cells called sinusoidal endothelial cells, and phagocytic Kupffer cells. Furthermore, hepatic stellate cells are one of the type of non-parenchymal cells found alongside perisinusoidal space, between a sinusoid and a hepatocyte, some intrahepatic lymphocytes are often found within the sinusoidal lumen. The functional lobes of the liver are separated by the imaginary plane called Cantlie's line that joins the gallbladder fossa to the inferior vena cava. The plane separates the liver into left and the right lobes. The middle hepatic vein also demarcates the true right and left lobes.


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