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Yes, the A express train goes from Penn Station to Chambers Street. It's 4 stops (unless you are traveling at night, when the A runs local). The Chambers Street station on the A and C trains is at Church Street.
The A train (of the A-C-E, the blue line). Take the Downtown A train from 175th Street to 34th Street-Penn Station. Entrance to the 175th Street station is included inside the bus terminal complex.
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The address 196 Allen Street is near the corner of Houston Street. The closest subway stop is 3 blocks west, the 2nd Avenue-Houston Street Station on the F train (of the B-D-F-M, the orange line).
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to Lexington Avenue-53rd Street. This station is connected to the 51st Street Station on the 6 train (of the 4-5-6, the dark green line), so you can transfer without exiting the subway system. Transfer to the 6, and take the Downtown 6 to 33rd Street, 28th Street, 23rd Street or 14th Street. All of these stops are on Park Avenue South.
Take the Uptown 1-2-3 (the red line), 1 stop, from 34th Street-Penn Station to 42nd Street-Times Square.Transfer at 42nd Street-Times Square to the Uptown 7train (the purple line). Take the Uptown 7 from the beginning of the line (42nd Street-Times Square) to the end of the line, Flushing-Main Street (at Roosevelt Avenue).
MetroNorth from Poughkeepsie goes to Grand Central. Amtrak from Poughkeepsie goes to Penn STation. It's very easy to take MetroNOrth to Grand Central and then get the subway to Penn Station.
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