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The cause is almost always an ignition system issue, cyl #2 is most likely getting no spark!

When these ignition components go bad, they can cause misfires:

Spark plugs, spark plug wires, and distributor; cap, rotor, coil(s), ignitor etc.

It is also possible that the fuel injector for cyl #2 is not spraying!

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Q: What would cause a miss fire on the number 2 cylinder?
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