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I'm currently working on the same problem on my 99. It could be any number of things. Check the vacuum system for kinks, cuts, or leaks in the lines, loose lines, etc. Check that the spark plug wires are securely fastened on both ends. Check to see if you're getting enough spark from the Ignition Control Module. (I haven't checked my spark yet). It also could be a problem with one of the sensors. Unfortunately, some of the sensors may not trigger a trouble code in light of the misfire problem, so you may have to seek out a diagnostic from a professional. I discovered a bad Coolant Temperature Sensor and replaced it. I no longer have the multiple misfire, though it has localized to the #7 cylinder. I wish I had something more specific for you, sorry!

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Q: What would cause multiple engine misfires in 1999 Chevy Suburban C1500 8 Cylinders 5.7L?
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