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Q: Where is ferritin and hemosiderin stored?
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Why is iron not stored or transported in its free form?

iron can not be storde or transported in its free form because is toxic. so it stored inside of cells as ferritin and hemosiderin


Which of these proteins functions to store or transport iron?

ferritin, hemosiderin, and transferrin


Are transferrin and ferritin stored in bone marrow?

yes


How is iron stores and transported in the body?

Iron taken in excess is stored in two forms ferritin and hemosiderin. Iron that is not used for erythropoiesis is stored in the mononuclear phagocytic system (MPS) or the reticloendothelial (RE) cells of the bone marrow, liver, and spleen. The body transports iron in hemoglobin which is the substance in the red blood cells which binds to oxygen to transport to the whole body.


What is hemosiderin-laden macrophage?

Hemosiderin is an iron-containing pigment derived in humans from ferritin. It can be found in macrophages in small amounts throughout a number of different tissues including the bone marrow, liver and the spleen as a normal way to store iron. Under certain conditions it can pathologically accumulate in excess amounts. In hemosiderosis macrophages are hemosiderin-laden but without associated damage to surrounding tissue. When there more extensive accumulation occurs, it can lead to surrounding tissue damage, scarring and organ dysfunction. This is called hemochromatosis.


Where ferritin is produced in body?

Ferritin is produced in nearly every cell in the body. Ferritin is a large protein that stores up to 4,500 iron atoms in its core. Iron has to be stored because we only absorb 10% of iron from our food meaning it is difficult to obtain and iron tends to participate in harmful free radical forming chemical reactions. Iron also cannot exist in the body by itself. Each atom has to be attached to a protein or small molecule (chelator) at all times or it will precipitate out of solution and will form rust in the body somewhat similar to the form it exists when it is stored in ferritin. Thus the need for ferritin to be produced by nearly all cells in the body, so there can be a reserve of iron in the body to supply the much needed iron and remove excess iron that could be harmful.


How are terms hemoglobin hemosiderin and hemolysis related?

they are related because of blood


What is hemosiderin?

A golden yellow or yellow-brown insoluble protein produced by phagocytic digestion of hematin; found in most tissues, especially in the liver, spleen, and bone marrow, in the form of granules much larger than ferritin molecules (of which they are believed to be aggregates), but with a higher content, as much as 37%, of iron; stains blue with Perl Prussian blue stain.


Is a ferritin level of 189 high?

Have ferritin level of 587 & a fatty liver & cholesterol of 6.9


What is Perls test?

a test for hemosiderin, utilizing Perls Prussian blue stain.


How come my ferritin level is 7 and my iron level 135 can you explain why i am so tired if my iron level is so high?

Ferritin is a protein that stores iron. Low ferritin is a precursor to anemia, so if you do nothing about the low ferritin level your iron level will eventually drop.


What is the normal range of ferritin?

is a level of 17.50 in ferritin blood test consider low in a male 66 years old