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Classical nuclear progesterone receptor (nPR) exists as two main protein isoforms (types of protein from a single gene) PR-A and PR-B. Progesterone is a steroid hormone allowing diffusion through the lipid membrane of mammalian cells. Therefore nPR-A and B are located in the cytoplasm. They move to the nucleus after ligand (progesterone) binding to control gene expression. Literature also exists to suggest that progesterone receptors exist at the cell surface, both alternative isoforms of nPR and structurally unrelated mPR proteins from a different gene.
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∙ 13y ago
Wiki User
∙ 13y agoovaries
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What are important tissue receptor tumor markers?
estrogen receptor, progesterone receptor, interleukin-2 receptor, and epidermal growth factor receptor.
What would happen if a hormone receptor did not bind to the right site?
I'm assuming you're asking what would happen if a receptor did not bind the proper hormone. The answer is a complex one because binding to a receptor does not necessarily mean that the receptor will be activated. Sometimes binding causes receptor inhibition; other times it can mean that the properties of the receptor change so that other hormones have an easier/harder time binding and activating it. But for the sake of giving an answer, let's say that we want to know what happens if a hormone binds and activates the wrong receptor. That answer is a relatively simple one: in most cases, the same events would take place that normally happen when the correct hormone binds the receptor. Let's take an example of a relatively uncommon cause of hypertension called hypertension exacerbated in pregnancy. In this condition, there's a mutation in the receptor for the hormone aldosterone that allows other hormones besides aldosterone (eg, progesterone) to bind it and activate it. When progesterone levels are high, as in pregnancy, the extra progesterone binds and heavily activates the aldosterone receptor, and the receptor essentially "thinks" that aldosterone has bound. So the action of progesterone at the aldosterone receptor are the same as aldosterone itself; since aldosterone is a major contributor to blood pressure, blood pressure increases to very high levels.
Are auditory receptor cells located in the anvil?
yes the auditory receptor cells are located in the anvil
In mastectomy procedurethe specimen has been harvested for estrogen and progesterone receptor studies in what solution you must put the specimen?
Formalin
Where are the receptor sights located for kinesthetic sense?
It depends on what the receptor cells are for. If they are for vision, they are located in the retina of the eye. If they are for hearing, they are located in the organ of Corti, and so on and so forth.
Where are the receptor cells for touch located?
skin
Where are receptor neurons for smell located?
high in each nostril
What is the sensory receptor for the eyes?
The rods and cones located in the retina.
What is double negatives?
I believe if means ER-, PR-, and Her2+ Estrogen Receptor, Progesterone Receptor, and the orphan receptor Her2/Neu. So it means that both of the hormone receptors (ER and PR) are not expressed by the tumor, but that other known markers, like Her2 are expressed. Expressing (being positive) is a good thing because it gives the clinicians something to target.
What is Double-Negative Breast Cancer?
I believe if means ER-, PR-, and Her2+ Estrogen Receptor, Progesterone Receptor, and the orphan receptor Her2/Neu. So it means that both of the hormone receptors (ER and PR) are not expressed by the tumor, but that other known markers, like Her2 are expressed. Expressing (being positive) is a good thing because it gives the clinicians something to target.
How is double negative breast cancer treated?
I believe if means ER-, PR-, and Her2+ Estrogen Receptor, Progesterone Receptor, and the orphan receptor Her2/Neu. So it means that both of the hormone receptors (ER and PR) are not expressed by the tumor, but that other known markers, like Her2 are expressed. Expressing (being positive) is a good thing because it gives the clinicians something to target.
What are the receptor sites for Leptin and Insulin?
are located in the same areas of the hypothalamus.
