TSP is caused by the HTLV-1 virus, which also causes leukemia. The virus can be spread through the placenta, and also through blood transfusions, breast-feeding, contaminated needles, and sexual contact.
It has been found all around the world (except in the poles), mainly in tropical and subtropical regions.
Tropical spastic paraparesis (TSP) is a slowly progressive spastic paraparesis caused by the human T-cell lymphotropic virus-1 (HTLV-1), with an insidious onset in adulthood.
isolated cases have been diagnosed in the southeastern United States and other places in the United States
TSP is most frequently found in: the Caribbean, Japan, the Seychelles Islands, regions of South America, western Africa
The disease may remain undetected for years after infection is contracted.
While the disease is incurable, significant improvement has been reported in the condition of TSP patients treated with corticosteroids
Infectious disease specialists use blood tests and magnetic resonance imaging (MRI) of the spinal cord to diagnose this condition.
TSP usually affects adults between the ages of 30 and 40, and is far more common in women than in men.
Physical therapy is designed to help restore and maintain useful movements or functions and prevent complications such as frozen joints, contractures, or bedsores.
20% of patients with TSP may also experience: deafness, double vision, dysmetria, exaggerated reflexes, facial paralysis, tremor.
The cause of HAM/TSP is still a matter of debate. Three hypotheses are considered by scientists as the most likely cause of TSP: direct toxicity, autoimmunity, and bystander damage.
significant improvement has been reported in the condition of TSP patients treated with corticosteroids. These drugs are believed to alleviate symptoms by suppressing the immune system's response to the virus that causes them.
the body's immune response may injure nerve tissue, causing symptoms that include bladder abnormalities, leg pain, loss of feeling in the feet, tingling sensations, and unpleasant sensations when the skin is touched.