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Meningitis, by definition, is an inflammatory process of the meninges, which constitute the blood brain barrier (BBB). Inflammation makes the blood brain barrier more permeable to chemicals, such as antibiotics. Under normal circumstances, penicillin does not cross the BBB very well, but when inflamed, it can cross more readily.
The antibiotics are carried directly to the lungs through the circulatory system. To reach the brain, they have to cross the blood/brain barrier.
Meningitis, by definition, is an inflammatory process of the meninges, which constitute the blood brain barrier (BBB). Inflammation makes the blood brain barrier more permeable to chemicals, such as antibiotics. Under normal circumstances, penicillin does not cross the BBB very well, but when inflamed, it can cross more readily.
IgG is the only antibody small enough to cross he placenta.
Astrocytes.
Netilmicin does not cross the blood-brain barrier.
"Bacterial cross-resistance happens when the two antibiotics that are being taken have very similar actions"
Yes. Certain medications are more likely to cross the meninges if the meninges are inflamed. Penicillins work in this way which is why they are so good in the treatment of meningitis. Once the inflammation goes down (so there is no longer a need for antibiotics) then the barrier is restored.
Yes. Valium (diazepam) does indeed cross the blood brain barrier. It is one of the more lipophilic of the benzodiazepine medications.
We just have one more barrier to cross; then we can lay siege to the castle.