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Intrinsic factor is produced in the fundus and body of the stomach by parietal cells that line the stomach. The purpose of intrinsic factor is so vitamin B can be absorbed in the small intestine.
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Aids in absorption of vitamin b12?
It is called intrinsic factor, which enables the absorption of B12. Intrinsic factor is found in the parietal cells (mucosa cells) of the stomach lining.
What happens when parietal cells shrink?
When these parietal cells shrink in size (atrophy), they produce less and less intrinsic factor
What the importance of intrinsic factor?
Intrinsic factor is glycoprotein that is produced by the parietal cells of the stomach.
How pernicious anemia cause achlorhydria?
pernicious anemia is a vitamin B12 deficiency. Vitamin B12 requires Intrinsic Factor to be reabsorbed by the ileum. Intrinsic Factor is produced by parietal cells in stomach. If there is some damage or manipulation of parietal cells, which also produce HCl, there will be less of both intrinsic factor causing B12 deficiency and HCl causing achlorhydria.
Is hydrochloric acid necessary to produce the intrinsic factor for cobalamin?
No, hydrochloric acid (HCl) is not necessary to produce the intrinsic factor for cobalamin. HCl is needed along with gastric enzymes to free Cobalamin (B12) from its polypeptide linkages in food. The intrinsic factor involved with the digestion and absorption of Cobalamin (B12) is a glycoprotein.
How stomach helps in erythropoiesis?
parietal cells which can be found in gastric gland of stomach secretes intrinsic factor, which is a type of glycoprotein. this intrinsic factor, together with vitamin B12 is required for effective absorption of iron in small intestine. iron is required in erythropoiesis to produce haemoglobin. if iron absorption is low, RBC production will be affected. in summary, stomach helps in RBC production by producing intrinsic cells required in iron absorption.
What is important function of the intrinsic factor found in the stomach?
the b12 intrinsic factor produced by the parietal cells in the stomach (parietal cells also produce HCL, the acid that dissolves food and converts pesinogen (secreted by the chief cells). B12 is necessary for carbohydrate, protein and fat to be used by the boy but most importantly b12 is necessary for all cells in the body (especially red blood cells) to work properly; if deficient in the body the person may develop pernicious anemia (due to the excessive destruction of immature blood cells or the lack of their production due to a lack of vitamin b12) as well as other problems such as problems with the nervous system sue to the fact that b12 is used to cover nerve cells thus the lack of vitamin b12 can also get to the brain and in kill the person. The intrinsic factor secreted by the stomach's parietal cells is used to absorb vitamin b12 as the body cannot absorb it on its own. As a result the intrinsic factor is essential for life as there will be vitamin vb12 deficiency if there is no intrinsic factor to help the boy absorb it. Another important fact is that vitamin b12 is absorbed( with the help of the intrinsic factor) by cubulin receptors in the ileum of the small intestine.
What is perniciousness?
This is anaemia (lowered blood haemoglobin) due to a lack of vitamin B12 absorbed from the intestinal tract, due to a lack of intrinsic factor usually. This can be due to auto antibodies against the cells that produce intrinsic factor, stomach ulcers crowding out the cells that produce intrinsic factor, a hereditary lack of intrinsic factor or the after effects of surgery, illness or fish tapeworm. This gives a macrocytic anaemia. Pernicious anemia is an autoimmune disease that renders the person unable to absorb sufficient Vitamin B-12. Eventually the person becomes Vitamin B-12 deficient and must be treated. Prior to the availability of treatment persons died from the disease, hence the name pernicious. It is critical that treatment be obtained as soon as possible. You can find more information at the following website: www.pernicious-anaemia-society.org
What stomach secretion is necessary for normal hemoglobin Production in RBC's?
Intrinsic factor is secreted by the parietal cells and is critical for absorption of B12. When the body attacks the parietal cells b12 deficiency results which is called "pernicious anemia."
Where does the absorption of vitamin B12 occur?
The vitamin B12 is a very important nutrient; it lowers risk of stroke, heart disease, cancer, Parkinson's, and Alzheimer's disease. The vitamin begins to absorb in the mouth, in contrast to most nutrients.
Why do you need intrinsic factor?
Intrinsic factor or gastric intrinsic factor is a protein produced by the stomach. It is used to absorb vitamin B12 in the small intestine. When there is a deficiency of the Intrinsic factor, there is a deficiency in the absorption of B12 into the body and this leads to pernicious anemia.
What is pernicious anemia and it's symptoms?
This is anaemia (lowered blood haemoglobin) due to a lack of vitamin B12 absorbed from the intestinal tract, due to a lack of intrinsic factor usually. This can be due to auto antibodies against the cells that produce intrinsic factor, stomach ulcers crowding out the cells that produce intrinsic factor, a hereditary lack of intrinsic factor or the after effects of surgery, illness or fish tapeworm. This gives a macrocytic anaemia. Pernicious anemia is an autoimmune disease that renders the person unable to absorb sufficient Vitamin B-12. Eventually the person becomes Vitamin B-12 deficient and must be treated. Prior to the availability of treatment persons died from the disease, hence the name pernicious. It is critical that treatment be obtained as soon as possible. You can find more information at the following website: www.pernicious-anaemia-society.org
