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Non-polar molecules (such as fatty acids, steroid hormones and O2) pass freely through the cell membrane.

Small uncharged molecules (such as H2O) also pass freely, but are slower.

Large, polar molecules and ions (such as Na+ and K+) do not pass freely.

Macromolecules (such as proteins and polysaccharides) do not pass through the cell membrane.

Molecules and ions that cannot pass freely through the cell membrane rely on other means, such as protein transporters, to move in to the cell.

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Q: Which molecues cross the membrane of a cell easily and which do not?
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