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Eight -- Jefferson, Madison, John Quincy Adams, Jackson, Lincoln, Grant,Cleveland and Benjamin Harrison, changed running mates for their re-election bid. Madison and Cleveland had no choice, since the VP died in office. Jackson's VP resigned to run for the Senate, but Jackson was happy to replace him. Adams' case was unusual- his VP, John Calhoun,ran with the opponent Jackson and was re-elected even though Adams was not.

(Franklin Roosevelt got a new VP for his 3rd term and changed again for his 4th term.)

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Q: Which presidents changed running mates to run for a second term?
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