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Depending on how far you want to walk, you can take the Uptown N-R-Q (the yellow line) from 42nd Street-Times Square to 59th Street-5th Avenue, and then walk up 5th Avenue to 72nd Street. The walk is a little over half a mile (0.8 km).

Or, you can take the Uptown N-R-Q to 59th Street-Lexington Avenue (the next stop after 59th-5th) and transfer to the Uptown 6 local train (of the 4-5-6, the dark green line). Take the Uptown 6, 1 stop, from 59th-Lexington to 68th Street-Hunter College (at Lexington Avenue). Then walk 4 blocks north to 72nd Street, and 3 blocks west to 5th Avenue: Lexington ---> Park ---> Madison ---> 5th. The walk is a little less than half a mile.

To me, it makes more sense to walk a little further and not have to transfer between subway lines, than to transfer just to save a little walking distance. But it's up to you.

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Q: Which subway line do you take from Times Square to 72nd Street and Fifth Avenue?
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