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Which type of mutation will probably have a larger effect A point mutation or a frameshift?
Wiki User
∙ 9y ago
Both types of mutation have the potential to cause a large effect.
In general, a frameshift mutation is more likely to cause a large effect. This is because it shifts the 'reading frame' - so that all of the subsequent codons (groupings of 3 bases that are read to determine which amino acid will be added) will be changed.
A point mutation is when a single base is replaced. This can either result in the same amino acid being added to the protein being synthesised (a silent mutation), a different amino acid being added (a missense mutation) or in a STOP codon (a nonsense mutation).
If a point mutation causes a premature STOP codon - this is quite likely to have a large effect on the protein.
Joany Funk
Wiki User
∙ 15y agoIt would occur more serious at the beginning of a gene
Wiki User
∙ 13y agoFrameshifts causes everything on a DNA sequence to shift and be misread; therefore, a mutation at the beginning changes more of the code.
Wiki User
∙ 13y agoI would assume that the mutation would be more harmful at the start, since more bases would be erroneous.
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