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Who is wytche stubberfield?

Updated: 8/21/2019
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Does omega 3 alpha linolenic acid make Dha?

Journal of Lipid Research, Vol. 43, 1537-1543, September 2002Copyright © 2002 by Lipid Research, Inc.Cordula Blank*, Mark A. Neumann, Maria Makrides and Robert A. Gibson1, * Department of Paediatrics and Child Health, Flinders Medical Centre, Bedford Park, South Australia 5042, AustraliaChild Nutrition Research Centre, Flinders Medical Centre, Bedford Park, South Australia 5042, AustraliaChild Health Research Institute, North Adelaide, South Australia 5006, Australia 1 To whom correspondence should be addressed. e-mail: rgibson@flinders.edu.au We examined the effect of altering the linoleic acid (LA, 18:2n-6) to -linolenic acid (ALA, 18:3n-3) ratio in the dietary fats of 3 day old piglets fed formula for 3 weeks. The LA-ALA ratios of the experimental formulas were 0.5:1, 1:1, 2:1, 4:1, and 10:1. The level of LA was held constant at 13% of total fats while the level of ALA varied from 1.3% (10:1 group) to 26.8% (0.5:1 group). Incorporation of the n-3 long chain PUFA EPA and 22:5n-3 into erythrocytes, plasma, liver, and brain tissues was linearly related to dietary ALA. Conversely, incorporation of DHA into all tissues was related to dietary ALA in a curvilinear manner, with the maximum incorporation of DHA appearing to be between the LA-ALA ratios of 4:1 and 2:1. Feeding LA-ALA ratios of 10:1 and 0.5:1 resulted in lower and similar proportions of DHA in tissues despite the very different levels of dietary ALA (1.3 vs. 26.8% of total fats, respectively). These results are relevant to term infant studies in that they confirm our earlier findings of the positive effect on DHA status by lowering the LA-ALA ratio from 10:1 to 3:1 or 4:1, and they predict that ratios of LA-ALA below 4:1 would have little further beneficial effect on DHA status. Abbreviations: AA, arachidonic acid; ALA, -linolenic acid; FAME, fatty acid methyl ester; LA, linoleic acid; LCPUFA, long chain polyunsaturated fatty acid; PL, phospholipid; PMR, pig milk replacer Supplementary key words brain • plasma • fatty acid metabolism • formulaThis article has been cited by other articles:S. M. Moore, K. J. Stalder, D. C. Beitz, C. H. Stahl, W. A. Fithian, and K. BregendahlThe Correlation of Chemical and Physical Corn Kernel Traits with Production Performance in Broiler Chickens and Laying HensPoult. Sci., April 1, 2008; 87(4): 665 - 676.[Abstract] [Full Text] [PDF]----M.-C. Huang, J. T. Brenna, A. C. Chao, C. Tschanz, D. A. Diersen-Schade, and H.-C. HungDifferential Tissue Dose Responses of (n-3) and (n-6) PUFA in Neonatal Piglets Fed Docosahexaenoate and ArachidonoateJ. Nutr., September 1, 2007; 137(9): 2049 - 2055.[Abstract] [Full Text] [PDF]----R. Portolesi, B. C. Powell, and R. A. GibsonCompetition between 24:5n-3 and ALA for {Delta}6 desaturase may limit the accumulation of DHA in HepG2 cell membranesJ. Lipid Res., July 1, 2007; 48(7): 1592 - 1598.[Abstract] [Full Text] [PDF]----R. G Metcalf, M. J James, R. A Gibson, J. R. Edwards, J. Stubberfield, R. Stuklis, K. Roberts-Thomson, G. D Young, and L. G ClelandEffects of fish-oil supplementation on myocardial fatty acids in humansAm. J. Clinical Nutrition, May 1, 2007; 85(5): 1222 - 1228.[Abstract] [Full Text] [PDF]----K. M. Heinemann, M. K. Waldron, K. E. Bigley, G. E. Lees, and J. E. BauerLong-Chain (n-3) Polyunsaturated Fatty Acids Are More Efficient than {alpha}-Linolenic Acid in Improving Electroretinogram Responses of Puppies Exposed during Gestation, Lactation, and WeaningJ. Nutr., August 1, 2005; 135(8): 1960 - 1966.[Abstract] [Full Text] [PDF]----P. L. L. Goyens, M. E. Spilker, P. L. Zock, M. B. Katan, and R. P. MensinkCompartmental modeling to quantify {alpha}-linolenic acid conversion after longer term intake of multiple tracer bolusesJ. Lipid Res., July 1, 2005; 46(7): 1474 - 1483.[Abstract] [Full Text] [PDF]-------- HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS