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Journal of Lipid Research, Vol. 43, 1537-1543, September 2002

Copyright © 2002 by Lipid Research, Inc.

Cordula Blank*, Mark A. Neumann, Maria Makrides and Robert A. Gibson1, * Department of Paediatrics and Child Health, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia

Child Nutrition Research Centre, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia

Child Health Research Institute, North Adelaide, South Australia 5006, Australia 1 To whom correspondence should be addressed. e-mail: rgibson@flinders.edu.au We examined the effect of altering the linoleic acid (LA, 18:2n-6) to -linolenic acid (ALA, 18:3n-3) ratio in the dietary fats of 3 day old piglets fed formula for 3 weeks. The LA-ALA ratios of the experimental formulas were 0.5:1, 1:1, 2:1, 4:1, and 10:1. The level of LA was held constant at 13% of total fats while the level of ALA varied from 1.3% (10:1 group) to 26.8% (0.5:1 group). Incorporation of the n-3 long chain PUFA EPA and 22:5n-3 into erythrocytes, plasma, liver, and brain tissues was linearly related to dietary ALA. Conversely, incorporation of DHA into all tissues was related to dietary ALA in a curvilinear manner, with the maximum incorporation of DHA appearing to be between the LA-ALA ratios of 4:1 and 2:1. Feeding LA-ALA ratios of 10:1 and 0.5:1 resulted in lower and similar proportions of DHA in tissues despite the very different levels of dietary ALA (1.3 vs. 26.8% of total fats, respectively). These results are relevant to term infant studies in that they confirm our earlier findings of the positive effect on DHA status by lowering the LA-ALA ratio from 10:1 to 3:1 or 4:1, and they predict that ratios of LA-ALA below 4:1 would have little further beneficial effect on DHA status. Abbreviations: AA, arachidonic acid; ALA, -linolenic acid; FAME, fatty acid methyl ester; LA, linoleic acid; LCPUFA, long chain polyunsaturated fatty acid; PL, phospholipid; PMR, pig milk replacer Supplementary key words brain • plasma • fatty acid metabolism • formula


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Q: Does omega 3 alpha linolenic acid make Dha?
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Are some fats essential for normal functioning?

There are two essential fatty acids that humans need to receive from food. All other fatty acids our bodies can make. The two essential fatty acids are alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an omega-6 fatty acid). Below is the previous answer: the join of two distinct points is a line


Can you get essential Omega-3 fatty acids from something other than fish oil?

Yes, you can get all the essential fatty acids from non-fish sources, even vegan sources. However, it isn't necessarily the easiest or most commonly-recommended way to get it. The two Omega-3 fatty acids in question are DHA and EPA. Alpha-linolenic acid (ALA) is another important Omega-3 but it's easy to get from vegetable oils. DHA and EPA are not so easy to get. Your body can make DHA and EPA from alpha-linolenic acid, but not efficiently. This is why many experts recommend fish oil. But the Vegan Society says: "Many factors affect the rate of conversion and one factor seems to be a high food intake of linoleic acid which is typical of vegan diets and may suppress the body's ability to convert alpha-linolenic acid to DHA. Vegans can achieve a better balance of PUFAs in their body tissues by using less sunflower, safflower and corn oils and more oils containing alpha-linoleic acid such as rapeseed (canola) oil, or soya bean and walnut oils. This would encourage their tissues to make more DHA."


How do you make a sentence with alpha and omega?

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What is best source of omega 3 for vegans?

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Can you guys make a alpha and omega 2?

This isn't the place to ask that.


Which one reason it is necessary for human to eat fat?

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