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Hepatic detoxification and excretion?
bilirubin (indirect vs. direct) and ammonia ....might just be overwhelmed from a hemolytic anemia....why getting a fractionated bilirubin is good....
Direct bilirubin (conjugated)?
post-hepatic...usually a duct obstruction...is water-soluble....if >50% look for obstructive issue....if <15%, think hemolysis....or hepatitis....
How does direct bilirubin appears normally in blood?
Dead hepatocytes release direct bilirubin in circulation
What does medical code 80076 stand for?
80076 is a CPT pathology and laboratory code for a: Hepatic function panel which must include: albumin; bilirubin, total; bilirubin, direct; phosphatase, alkaline; protein, total; transferase, alanine amino (ALT) (SGPT); transferase, aspartate amino (AST) (SGOT).
What is the condition when the direct and indirect bilirubin is slightly raised and SGPT and SGOT are within normal limits?
Bilirubin total is 3.00 mg/dL, bilirubin direct is 1.50 mg/dL/bilirubin indirect 1.50/mg/dL ....what does this mean. Is is OK or dangerous. What is the medicine please
Is total bilirubin 0.9?
Bilirubin is measured in milligrams per deciliter (mg/dL). An example of normal values for adults is: Total bilirubin: 0.3 to 1.9 mg/dL. Direct bilirubin: 0.0 to 0.3 mg/dL.
What does cpt code 82247 stand for?
82247 -BILIRUBIN; TOTAL Liver Function test , includes the total , direct and indirect bilirubin.
What is the significance of 1.5mg bilirubin lab results?
Depends on if you're talking about a newborn or an adult. Newborns have a higher normal range than adults. For instance, in Colorado we establish a certain range from the normal population that may differ from the rest of the nation. Adults can run up to 1.0 mg/dl. Anything from 0 to 1.0 mg/dl is considered normal. 1.5 mg/dl is high and may require additional lab work or other studies to determine the cause of the high bilirubin. The physician may request that the lab break the bilirubin test down into direct vs. indirect bilirubin. Direct bilirubin is a measure of how much of the bilirubin is not soluble and therefore not excreted in the urine. Sunlight can actually "conjugate the bilirubin" to make it more soluble in the urine and therefore excretable in the urine. This is why they put babies with "jaundice" or high bilirubin under bili lights. Bili lights will help turn the unconjugated biliruben into soluble biliruben which can then be excreted in the urine. Increased bilirubin in adults can point to several disease states like cirrhosis of the live due to viral hepatitis, alcoholism or other factors. Very high bilirubin levels in infants can cause brain damage, so treatment like exchange transfusion may be in order.
Bilirubin - blood?
DefinitionBilirubin is a yellowish pigment found in bile, a fluid produced by the liver.This article discusses the laboratory test done to measure bilirubin in the blood. Total and direct bilirubin are usually measured to screen for or to monitor liver or gallbladder problems. Large amounts of bilirubin in the body can lead to jaundice.A test may also be done to measure bilirubin in a urine sample. For information on that test, see: Bilirubin - urine.Alternative NamesTotal bilirubin - blood; Unconjugated bilirubin - blood; Indirect bilirubin - blood; Conjugated bilirubin - blood; Direct bilirubin - bloodHow the test is performedA blood sample is needed. For information on how this is done, see: Venipuncture.The laboratory specialist spins the blood in a machine called a centrifuge, which separates the liquid part of the blood (serum) from the cells. The bilirubin test is done on the serum.How to prepare for the testYou should not eat or drink for at least 4 hours before the test. Your health care provider may instruct you to stop taking drugs that affect the test.Drugs that can increase bilirubin measurements include allopurinol, anabolic steroids, some antibiotics, antimalaria medications, azathioprine, chlorpropamide, cholinergics, codeine, diuretics, epinephrine, meperidine, methotrexate, methyldopa, MAO inhibitors, morphine, nicotinic acid, birth control pills, phenothiazines, quinidine, rifampin, steroids, sulfonamides, and theophylline.Drugs that can decrease bilirubin measurements include barbiturates, caffeine, penicillin, and high-dose salicylates such as aspirin.Why the test is performedThis test is useful in determining if a patient has liver disease or a blocked bile duct.Bilirubin metabolism begins with the breakdown of red blood cells in many parts of the body. Red blood cells contain hemoglobin, which is broken down to heme and globin. Heme is converted to bilirubin, which is then carried by albumin in the blood to the liver.In the liver, most of the bilirubin is chemically attached to another molecule before it is released in the bile. This "conjugated" (attached) bilirubin is called direct bilirubin; unconjugated bilirubin is called indirect bilirubin. Total serum bilirubin equals direct bilirubin plus indirect bilirubin.Conjugated bilirubin is released into the bile by the liver and stored in the gallbladder, or transferred directly to the small intestines. Bilirubin is further broken down by bacteria in the intestines, and those breakdown products contribute to the color of the feces. A small percentage of these breakdown compounds are taken in again by the body, and eventually appear in the urine.Normal ValuesDirect bilirubin: 0 to 0.3 mg/dLTotal bilirubin: 0.3 to 1.9 mg/dLNote: mg/dL = milligrams per deciliterNormal values may vary slightly from laboratory to laboratory.What abnormal results meanJaundice is a yellowing of the skin and the white part of the eye, which occurs when bilirubin builds up in the blood at a level greater than approximately 2.5 mg/dL. Jaundice occurs because red blood cells are being broken down too fast for the liver to process. This might happen due to liver disease or bile duct blockage.If the bile ducts are blocked, direct bilirubin will build up, escape from the liver, and end up in the blood. If the levels are high enough, some of it will appear in the urine. Only direct bilirubin appears in the urine. Increased direct bilirubin usually means that the biliary (liver secretion) ducts are obstructed.Increased indirect or total bilirubin may be a sign of:Crigler-Najjar syndromeErythroblastosis fetalisGilbert's diseaseHealing of a large hematoma (bruise or bleeding under the skin)Hemolytic anemiaHemolytic disease of the newbornHepatitisPhysiological jaundice (normal in newborns)Sickle cell anemiaTransfusion reactionPernicious anemiaIncreased direct bilirubin may indicate:Bile duct obstructionCirrhosisDubin-Johnson syndrome (very rare)HepatitisIntrahepatic cholestasis (buildup of bile in the liver) due to any causeAdditional conditions under which the test may be performed:Biliary strictureCholangiocarcinomaCholangitisCholedocholithiasisHemolytic anemia due to G6PD deficiencyHepatic encephalopathyIdiopathic aplastic anemiaIdiopathic autoimmune hemolytic anemiaImmune hemolytic anemia (including drug-induced immune hemolytic anemia)Secondary aplastic anemiaThrombotic thrombocytopenic purpuraWilson's diseaseSpecial considerationsFactors that interfere with bilirubin testing are:Hemolysis (breakdown) of blood will falsely increase bilirubin levelsLipids in the blood will falsely decrease bilirubin levelsBilirubin is light-sensitive; it breaks down in lightReferencesBerk PD, Korenblat KM. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 150.
What liver function tests are most useful?
the liver function enzymes and the ratio of direct to total bilirubin.
What is the cpt for hepatic function panel?
The Hepatic Function Panel is a group of clinical laboratory blood tests used for the evaluation of a patient with symptoms of liver disease or injury. It includes diagnosis and quantitative assessment of the disease and monitoring the effects of certain medications on the liver. The tests contained in the Hepatic Function Panel are designed to measure multiple aspects of hepatocyte function, including biliary conjugation and excretion, hepatocellular metabolism, and protein synthesis. The Hepatic Function Panel consists of the following tests: • Albumin • Bilirubin; total • Bilirubin; direct • Phosphatase; alkaline • Protein, total • Transferase; alanine amino (ALT)(SGPT) • Transferase; aspartate amino (AST)(SGOT) Once a diagnosis is established, one or several specific tests are usually adequate for monitoring the course of the disease and its resolution.
What are the normal values of indirect and direct bilirubin?
Total(Indirect + Direct) = 2-17 micromol/LDirect = 0 - 5 micromol/Lin an adult upto 1.0mg/dl.in neonate upto 10mg/dl
