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Why do people with cystic fibrosis have more sodium chloride in their system?
Wiki User
∙ 15y ago
Because the sweat glands secretes more salt above 150 mg.
Wiki User
∙ 15y ago
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How are cells affected by cystic fibrosis?
Cystic fibrosis affects the epithelium which is one of the four most basic types of tissue in animals. Chloride and sodium don't properly move across the cells producing a thick, sticky substance.
What cells are affected by cystic fibrosis?
The protein affected by cystic fibrosis is called the cystic fibrosis transmembrane conductance regulator or CFTR. CFTR acts as a channel that transports negatively charged chloride ions into and out of cells. This helps control the flow of water in tissues. CFTR also regulates the function of other channels that transport positive sodium ions into and out of cells.
What is cystic fibrosis gene disorder?
The genes on each chromosome control specific functions of the human body. The gene on chromosome 7 produces a protein called cystic fibrosis transmembrane regulator. Mutation in the DNA level of chromosome 7 leads to the absence of this protein which leads to cystic fibrosis. Cystic fibrosis is a recessive disease. It means that both copies of the gene must be defective. An affected person will have abnormal cystic fibrosis transmembrane regulator gene on each chromosome 7. Therefore both biological parents must have an abnormal gene. One abnormal copy is inherited from each parent. A person with one normal gene and one abnormal gene is called a cystic fibrosis carrier. Cystic fibrosis carriers do not show any symptoms but they may pass the abnormal gene to their children. Therefore the parents can be either cystic fibrosis carriers or affected themselves.
What do scientists currently believe is the cause of Cystic Fibrosis How are the faulty gene inherited and what direct effect does that have on the affected cells?
The faulty gene causes the misfolding of a protein called the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR is responsible for the movement of chloride and sodium ions into and out of cells. The lack of salt and water on the surface of the cells causes the mucus to become extremely thick and sticky which builds up in and clogs organs.
Why do salt crystals form on the skin of people with cystic fibrosis?
Copied and edited from someone else's answer on a similar question (they're not registered on WikiAnswers or I'd reference them): They form because the water from their sweat evaporates and then the salt can't go with it! You might like to check the other questions regarding salt and cystic fibrosis as I don't think the above answer quite covers your question.
Sweat electrolytes test?
DefinitionSweat electrolytes is a test that measures the level of chloride in sweat. Although genetic tests have become important methods for determining whether a child has cystic fibrosis, the sweat chloride test remains important.Alternative NamesSweat test; Sweat chloride; Iontophoretic sweat testHow the test is performedIn the first part of the test, a colorless, odorless chemical that causes sweating is applied to a small area on an arm or leg. An electrode is then attached to the arm or leg, which allows the technician to apply a weak electrical current to the area to stimulate sweating.People may feel a tingling sensation in the area, or a feeling of warmth. This part of the procedure lasts approximately 5 minutes.The next part of the test involves cleaning the stimulated area and collecting the sweat on a piece of filter paper or gauze, or in a plastic coil. After 30 minutes, the collected sweat is sent to a hospital laboratory for analysis. The entire collection procedure takes about 1 hour.How to prepare for the testNo special preparation is necessary. Make sure the center where the test is being performed is a cystic fibrosis testing center.How the test will feelThough the test is not painful, some people describe a tingling sensation at the site of the electrode. In smaller children or infants, the sensation can cause irritability or discomfort.Why the test is performedSweat testing is the standard method for diagnosing cystic fibrosis. People with cystic fibrosis have higher amounts of sodium and chloride in their sweat, which the test can detect.Some people are referred for testing because of symptoms such as poor growth, many respiratory infections, or foul-smelling stools. In some states, newborn screening programs test for cystic fibrosis, and the sweat test is used to confirm these results.Normal ValuesA sweat chloride test result less than or equal to 39 mEq/L in an infant over 6 months old probably means cystic fibrosis is not present.A result between 40 - 59 mEq/L does not give a clear diagnosis. Further testing is needed.If the result is 60 mEq/L or greater, cystic fibrosis is present.Note: mEq/L = milliequivalent per literNormal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.What abnormal results meanAn abnormal test may indicate the presence of cystic fibrosis.ReferencesBoat TF, Acton JD. Cystic fibrosis. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics.18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 400.Farrell PM, Rosenstein BJ, White TB, et al. Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic fibrosis consensus report. Journal of Pediatrics. Aug 2008;153(2).
Why is sodium chloride given to people?
Sodium is a chemical element indispensable for life and the source is the sodium chloride intake; sodium is essential for the blood system.
What type of atom is in sodium chloride?
Sodium chloride has two atoms in the formula unit (NaCl): sodium and chlorine.
Which substance is a compound carbon chloride sodium chloride sodium?
Sodium chloride is a compound.
Is sodium chloride carcinogenic?
Sodium chloride is not a cause of cancer.
What elements are in salt?
Sodium and Chlorine = Sodium Chloride that makes people sick.
Is sodium chloride or sodium fluoride stronger?
sodium chloride
