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Why do we call MHC proteins a self-antigen?

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Connie Ferry

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Q: Why do we call MHC proteins a self-antigen?
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What are the cells that target the MHC proteins on another cell?

macrophages


Which class of MHC proteins presents exogenous antigens?

Class ll


The function of an antigen-presenting cell depends on the presence of what?

MHC proteins.


Are MHC 1 proteins found on most cells of the body?

yes


What genes are responsible for coding for self proteins?

MHC (major histocompatibility complex)


Four of the five cells listed - viruses cells - MHC markers - cancer cells - bacteria - dead cells - are targets of the immune system - Select the exception?

MHC markers- which are proteins that present or "show" antigens like bacteria to other immune cells. Instead of being targets, they are helper proteins of the immune system.


What material acts like a marker on the outside of the cell for other cells?

At the heart of the immune response is the ability to distinguish between 'self' and 'non-self.'Every cell in your body carries the same set of distinctive surface proteins that distinguish you as 'self.' Normally your immune cells do not attack your own body tissues, which all carry the same pattern of self-markers.This set of unique markers on human cells is called the major histocompatibility complex (MHC). There are two classes: MHC Class I proteins, which are on all cells, and MHC Class II proteins, which are only on certain specialized cells.


Difference between MHC class1 and MHC class2 molecules?

MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.


What does the medical abbreviation MHC mean?

MHC = major histocompatibility complex What makes up MHC are HLA's (human leukocyte antigens), which there are subclasses for.


How does involvement of MHC 1 and MHC 2 help immune system?

MHC IMHC I is present in all cells except red blood cells (they lack nuclei). MHC I will present an intravesicular antigen to the cells surface for it to be identified as self or foreign by your adaptive immunity cells.MHC IIMHC II is present in professional antigen presenting cells which include: macrophages, B cells and dendritic cells. These cells will engulf bacteria, soluble proteins, viruses, etc. Whatever was taken into the cell becomes processed in the increasingly acidic endosome that eventually will cut the antigen into peptides. MHC II transported from the ER will meet up with this endosome and the peptides will bind to MHC II for it to eventually present on the cells surface.


When was MHC Krylya Sovetov created?

MHC Krylya Sovetov was created in 2008.


Which of the types of cells display protein fragments produced by the cancer within them?

All nucleated cells bring pieces of endogenous proteins to the surface to display on the MHC protein.