Why does Amoeba Dubai have a genome that is 200 times larger than the human genome?

Answer 1

Why each cell contains 200 times more genetic material than a human cell is not known, however, because the biomass of all the Amoeba dubia is probably thousands, if not tens of thousands of times larger than the entire human population of the Earth there is also the potential for much more genetic variation.

The number of amoebas is very large. As such there can be duplication of the genome and mutation taking place simultaneously. When both things happen simultaneously, the defect is probably carried forward. This procedure can be repeated many times to give you such a large sized genome. In such cases the cell organelles and other genetically directed things will take course like the whorl. So making small changes in structures and functions of the cell organelles and other proteins.