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Why does a patients body is less likely to reject an allograft if it comes from a close relative?
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Why is a patient more unlikely to reject an allograft if it comes from a close relative?
Because, genetically - the donated 'cells' are a closer match to the patient's DNA structure than if they came from a stranger. This means that the patient's immune system is more likely to accept the donation than reject it.
Why does a patient's body is less likely to reject and allograft if it comes from a relative?
Because it is more likely that a relative will have the same MHCs (major histocompatibility complexes) on their cells. When immune cells patrol the body they will bind these complexes which tell them whether the cell they are binding is 'self" or "nonself". If they bind a MHC which they percieve as nonself, they may initate an immune response leading to rejection of the graft
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