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The destruction of ACh receptors makes skeletal muscle less responsive to nerve stimulation and more likely to prematurely fatigue. With fewer ACh receptors available to bind to ACh, the skeletal muscle cell membrane potentials have a more difficult time reaching the threshold potential and initiating contraction. Thus, the normal degree of fatigue noted during repetitive nerve stimulation is exacerbated in an individual with myasthenia gravis.

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Q: Why does repetitive nerve stimulation result in decreased amplitude of the muscle contraction?
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