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Q: Why is acetanilide nitrated and not aniline?
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What is an acetanilid?

An acetanilide is an amide derived from acetic acid and aniline, once used as an analgesic and antipyretic.


Among benzyl amine aniline acetanilide and p-nitro aniline which is the most basic compound?

benzyl amine is the most basic


Why add of little amount from acetic anhydride in synthesis of acetanilide?

Acetic anhydride and aniline are the reactants for the preparation of acetaanilide.


monobromination of acetanilide occurs,while tribromination of aniline would occur under the same conditions?

Write a detailed set of equations for the acetylation reaction, and in particular show clearly that the reaction can be regarded as a nucleophilic substitution, in which the attacking nucleophile is aniline (attacking acetic anhydride).


Which is strong base aniline or o-nitroaniline?

Dyes are of several types they may be acidic , basic or neutral, organic dyes are mostly basic.


Which is more basic cyclohexyl aniline or aniline?

Strength of bases is related to the ease of accepting a proton which inturn depends on the availability of electron pair on the nitrogen atom (or some other basic atom). More is the availability of electron pair, more easily the proton will be accepted and more will be the basic strength.Aniline is a weaker base than ammonia or cyclohexylamine. It is because of the fact that the electron pair on nitrogen is involved in delocalization, making it less available for donation.


Why aniline is more reactive than acetanilide toward electrophilic substitution?

For acetanilide, resonance delocalization of the nitrogen lone pair electrons to the aromatic ring is less favored because the positive charge on nitrogen is next to the positively polarized carbonyl group. Resonance delocalization to the carbonyl oxygen is favored because of the electronegativity of oxygen. Since the nitrogen lone pair electrons are less available to the ring than in aniline, the reactivity of the ring toward electrophilic substitution decreases.


Why can't acetanilide dissolve in HCl?

Why is not acetanilide soluble in HCL?


What is the purpose of adding sodium acetate to the reaction mixture in preparation of acetanilide?

In the synthesis of acetanilide the hydrochloride salt of aniline is used in order to increase the solubility in water. The sodium acetate acts as a base and reacts with the HCl to produce acetic acid. Once the acetanilide product is no longer a hydrochloride salt, its solubility in water is decreased and it crystalises out. The main byproducts are sodium chloride and acetic acid which remain soluble in the water and are removed when the crude product is filtered off.


Most suitable for recrystallizing acetanilide?

the most suitable for recrystrallizing acetanilide is water..


Will acetanilide dissolve in hot heptane?

Yes. Heptane is an ideal recrystallization solvent for acetanilide.


How can you prepare para-nitro acetanilide from acetanilide?

used of para nitro acet anilide