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Baking Soda (sodium bicarbonate)

Why is sodium bicarbonate used to help increase the poor absorption of a drug?

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Wiki User
November 27, 2008 1:57AM

because orally ingested drugs have to be soluble and is a major synthetic goal of medchem scientists

the way you make a drug more soluble is to make it an ion (thats why you see many drugs are XXXXX HCl) and bicarbonate can be used to abstract an acidic hydrogen from the drug molecule and make it ionic (so more soluble)