9-fluorenone is different because it is a ketone with all of its carbons tied up in double bonds. There are no readily available acidic hydrogens, therefore this makes the pka of the molecule much greater than most other ketones.
9-fluorenone is different because it is a ketone with all of its carbons tied up in double bonds. There are no readily available acidic hydrogens, therefore this makes the pka of the molecule much greater than most other ketones.
9-Fluoreneone is different from many ketones as it does not have any acidic protons alpha to the ketone. The only protons available are attached to the aromatic rings, so the pKa would be fairly similar to, perhaps slightly lower than, the pKa of benzene, 43.
The pKa, or acid dissociation constant, of an amino acid is strongly tied to the properties of the surrounding solvent. The hydrophobic core of a protein is a distinctly different environment than the water exposed surface of the protein and the pKa in the core is different than the normal, solvent exposed pKa. This is related to the dielectric constant, or the ease at which charge is "felt" over a distance, which is much lower in the hydrophobic core of the protein. In addition, the now fixed locations of other possibly charged amino acids nearby will also impact the pKa of the residue.
pKa=40
how do you calculate pKa
pKa=2.86
9-Fluoreneone is different from many ketones as it does not have any acidic protons alpha to the ketone. The only protons available are attached to the aromatic rings, so the pKa would be fairly similar to, perhaps slightly lower than, the pKa of benzene, 43.
The pKa, or acid dissociation constant, of an amino acid is strongly tied to the properties of the surrounding solvent. The hydrophobic core of a protein is a distinctly different environment than the water exposed surface of the protein and the pKa in the core is different than the normal, solvent exposed pKa. This is related to the dielectric constant, or the ease at which charge is "felt" over a distance, which is much lower in the hydrophobic core of the protein. In addition, the now fixed locations of other possibly charged amino acids nearby will also impact the pKa of the residue.
pKa=40
how do you calculate pKa
Er... Oil doesn't normally have a pKa, as oil isn't an acid. It's non-polar.
pKa=2.86
pKa = 15
It is around pKa=13
Doxofylline Pka value is about 9.8.
pKa (dissociation constant) is variable with temperature.
The pka of a protonated ether (the conjugate acid) is about -3.5
The pKa of sulfonic acid is < 0