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This is necessary because drugs need to be able to pass through cell membranes ( that's exclude strong acids and bases) and dissolve in the stomach and blood ( that's favor acids and bases). If a compound is too basic or acidic, it won't be able to cross the cell membranes and leave the digestive tract; if it's not acidic or basic at all, it won't dissolve well in the blood so it won't be carried efficiently throughout the body.

If you want to get a little more into the chemistry of it, acids and bases gain and lose protons, which gives them ionic charges. Charged particles dissolve well in water, so acids and bases dissolve well. Charged particles can't pass throu...gh layers of uncharged molecules like those that make up the cell membrane, though. Weak acids and bases have the advantage that they're sometimes in their ionized state and sometimes in their unionized state, so they can dissolve, get through the cell membrane and then re-dissolve in the blood.

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13y ago
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11y ago

some oral drugs are weak acids but most of oral drugs are weak bases

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Q: Why many drugs are weak acids and weak bases?
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