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A live herpes virus, as it naturally occurs, has to be attenuated somehow to produce a safe vaccine so that it doesn't induce an undesireable active infection with outbreaks. The virus is genetically modified so that it will produce the desired immune response in the patient, while not causing problems. It is desirable that the virus remains latent in the patient to produce a continuing supply of antibodies while not producing active outbreaks, obviously. There is work ongoing relating to such live virus vaccines for herpes, but it will be several years, assuming any of them are successful, before any will be available. Rajah - The Original Herpes Home Page

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Q: Why might genetically engineered vaccines be safer than traditionally made vaccines?
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