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Drugs with a low therapeutic index have a narrow margin of safety.
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The therapeutic index of drugs is the ratio between the amount of drug needed to kill 50% of the cells of the experimental animals and the dose needed for 50% of the cells to respond. The larger the therapeutic index, the safer the drug.
It is for certain drugs such as Digoxin as they have such a narrow therapeutic index. For drugs with a wide range of therapeutic index, the best measure of safety is the maximum daily dose, its effect on the patient and what other drugs it interacts with. Ask your pharmacist for specific safety questions on your specific drugs.
Yes these are the antibiotics which have the highest therapeutic index.. That too penicillin is exceptionally high... The only side effect which is considered significant from these two groups of antibiotics is Hypersensitivity reaction or allergis reaction which can be lethal also in some of them.. The reason is, both of these belong to a group of beta lactum antibiotics and they both have a protein structure and they are easily metabolised in the body.. If they ast on bacteria than they are antibiotics otherwise they are mere protein food, just like giving parentral nutrition... Hence they have a huge therapeutic index..
Digitalis has a very narrow therapeutic index, therefore, the dose must be carefully be monitored for each patient.
No. Foods with high refined sugar amounts have a high glycemic index.
Toxicity of any drug is described by its Therapeutic Index--the ratio of lethal dose to effective dose. For instance, if the effective dose--the dose that gets you high--of Soma (the fake one in Brave New World, not carisoprodol) is 10 ng/ul and the lethal dose is 100 ng/ul, Soma's therapeutic index is 10. Marijuana has no therapeutic index as it has no lethal dose. The only other drug I know of that can come close to saying that is LSD, whose lethal dose is 12,000 micrograms--this for a drug that's normally taken 100 micrograms at a time. (Given that, erowid reports that ONE person has died of an LSD overdose; the guy thought it was speed and injected 320mg--not micrograms but milligrams--of acid.)
therapeutic products
in a book there is a section that tells you where things are.
A transparent medium is sometimes said to have a high optical density (or to be relatively dense) if it has a high refractive index.
high penetration index shows low temperature susceptibility, low penetration index shows high temperature suspectibility.