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Doxofylline Pka value is about 9.8.
pKa = 15
It is around pKa=13
By following + or - 2 pH to the pKa value
The pka of a protonated ether (the conjugate acid) is about -3.5
The conjugate acid is Hydrogen (H2), the pKa of which is 35.
3.3
7.6
if Pka value is more for acidic drug,best side for absorption will be throughout the G.i.Tract.
pKa = 6.36 of carbonic acid to HCO3-
actual pka of betaxolol is 9.4 but observed is 9.38
The pKa of sulfonic acid is < 0