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It depends on your definition of knot. There are often large deposits of fatty tissue called sebaceous cysts which are benign and harmless and can often last for years, sometimes lifetimes. the main difference between a "knot" and a "cyst" would be that a knot suggests it came about as a result of an injury. If you are concerned, check with a dermatologist...

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Q: Why would a knot last longer than a year?
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