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Why would an insertion or deletion mutation have more effect than a substitution mutation?
Wiki User
∙ 9y ago
Base-pair insertions have a greater effect because they shift the information on the DNA down and change all following information, whereas substitutions may change only one amino acid or have no effect.
-The base-pairs code for amino acids in groups of three. If just one base is added in, then this grouping is shifted upstream by one. The incorrect amino acids will be coded for and added to the protein being built. It could possibly stop the protein from being synthesized fully if the change creates a stop codon. This usually hinders the protein from functioning.
-Base-pair substitution mutations only affect the codon (set of 3 base pairs) that it actually occurs in. If the mutation is in the first base-pair of the codon then the amino acid will change. If the mutation is in the second or third position of the codon then amino acid may or may not change; this is because amino acids can be coded for by more than one codon, but the first base-pair (and sometimes the second) is usually the same. A substitution can also change a codon to a stop codon. This may keep the amino acid the same, change only one amino acid (which does not always stop the protein from working), or cause the protein to prematurely stop being built.
Wiki User
∙ 13y ago
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What effect does deletion mutation have on the chain?
It will shorten the chain.
Explain how a mutation could have no effect on the organism?
It can have absolutely no affect, a bad affect, or even a good affect.*Deletion and Addition are frameshift: most harmful.
What are 3 ways mutations can effect an organism?
Three ways mutations can occur in genes are: 1. Insertion: Extra DNA nucleoties are added to the DNA strand. 2. Deletion: DNA nucleotides are deleted, therefore, changing the DNA sequence. 3. Translocation: parts of chromosomes are exchanged.
Why does a mutation in a sex cell have potential for great effect?
A mutation in a sex cell can be passed on to your offspring and to their offspring as well. Therefore, its effect is greater than that of a somatic mutation.
What is the result of mutation during of meiosis?
The mutation may be passed on to an offspring. Depending on the mutation, it may have no effect, or it could be lethal.
What a is mutation?
A mutation is simply a change in your genes or DNA sequence. The types of mutations in Biology are: substitution, insertion, deletion, and frame-shift. Contrary to popular belief, mutations are often harmless.
What effect does deletion mutation have on the chain?
It will shorten the chain.
What are two types of frame shift mutations?
"I believe there is insertion and deletion, (one kind), and substitutions. (the second kind)" This answer is incorrect, the two types of frameshift mutation are insertion and deletion, these both alter the translation reading frame. A substitution point mutation in DNA is referred to as a single-nucleotide polymorphism and does not result in any change to the translational reading frame. insections and deletions are two types of frameshift mutations
Why frameshift mutations have greater effect than point mutations?
A substitution mutation means that one base was copied incorrectly within a string of DNA. Since it takes three DNA bases to code for a single amino acid, only one amino acid is affected. A frameshift mutation, on the other hand, refers to an insertion or deletion of any number of DNA bases NOT divisible by three. This mutation throws off EVERY other amino acid after it and tends to be devastating. For example, if you had this sequence: actgactga, you would get three amino acids: act, gac, and tga. If you had a substitution error, it might yield cctgactga. In this case, only the first acid would be different. In the case of an insertion (one type of frameshift mutation), you might get: acttgactga. As you can see, a t-base has been added towards the beginning. in this case, you would get the amino acid sequence: act, tga, ctg. EVERY amino acid following the mutation is different from what it should be.
Which mutation occurs when one nucleotide base in replaced with another base?
the substitution has little effect because UGU and UGC both translate into the same amino acid--cysteine.
Explain how a mutation could have no effect on the organism?
It can have absolutely no affect, a bad affect, or even a good affect.*Deletion and Addition are frameshift: most harmful.
What is point mutation substitution?
When a nitrogen base is substituted for a different one so it may code for a different amino acid. Sometimes substitution still codes for a same amino acid, in which case it becomes a silent mutation, but in other times it may alter the protein entirely.
What small-scale mutation would be most likely to have a catastrophic effect on the functioning of a protein?
Base-pair deletionA base-pair deletion// An error in the repair of damaged DNA
Why does a deletion mutation usually cause more defects during protein synthesis than a point mutation?
Deletion mutations can affect the entire base sequence.
What is a mutation called that has no effect on an organism?
A point mutation, in which one nitrogen base in a codon is substituted for another, may have no effect on an organism. This is true if the base substitution does not change the amino acid that the codon represents, or if the mutation occurs in a non-critical location in the protein so that the protein's structure is not changed significantly and the protein is still able to function.
Which of the following types of mutation resulting in an error in the mRNA just after the AUG start of translation is likely to have the most serious effect on the polypeptide product?
a deletion of 2 nucleotides
Price effect is a combination of income effect and substitution effect?
Yes, Price effect = substitution effect + income effect
