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Depending on the cause and location of the puncture wound, SMX/TMP may help prevent infection of the wound. Puncture wounds are notoriously difficult to clean and are at higher risk of infection, especially if on the foot, hand, or lower extremity.

Regarding whether to take the medication if you have anemia, it depends on the cause of your anemia. If you have a vitamin-deficiency anemia or anemia caused by bleeding, it should not matter. If you have glucose-6 phosphate dehydrogenase deficiency, you should not take this medication because it may cause a breakdown in your red blood cells, resulting in worsened anemia. Discuss with your physician whether taking this medication is appropriate for your particular circumstances.

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Q: Why would your doctor prescribe you SMZ TMP for a puncture wound And should you take this since you have anemia?
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