Pilocarpine lowers the heart rate.
atropine sulfate is used as an antidote of anticholinesterase meds administered on patients with myasthenia gravis. Atropine sulfate should be also made available when performing the Tensilon Test to reverse the effect of Edrophonium injection.
Pilocarpine stimulates the release of acetylcholine from parasympathetic neurons. Therefore, it stimulates the effect of vagal stimulation on the heart.
Non depolarization means the muscle relaxant effect will stay in the body. needs to reverse with prostigmine and atropine.
Pilocarpine is actually a Muscarinic cholinergic receptor (mAChR) agonist. It works on the Parasypathetic nervous system; therefore, it makes sense that the agonist working on the PNS would result in decreased heart rate. Atropine, in contrast, is an muscarinic cholinergic receptor antagonist and will lead to increased heart rate due to the lowered effect of the parasympathetic system on the heart.
Mary Freyer Montgomery has written: 'Studies on the thirst mechanism' -- subject(s): Atropine, Pilocarpine, Salivary glands, Thrist, Thirst
pilocarpine as a muscuranic agonist, increases tone and motility of intestinal muscles and of urinary tract and billiary duct's smooth muscles.
Check out the atropine page at wikipedia.org for your answer.
Atropine is a cholinergic antagonist which blocks the acetylcholine receptor causing increased sympathetic tone increasing the heart rate
Physostigmine inhibit AchE (the enzyme that hadrolyse Ach), so Ach accumulate at synaptic cleft and banish the effect of atropine
Pilocarpine is often used as an antidote for scopolamine, atropine, and hyoscyamine poisoning. like scopolamine, 3-Quinuclidinyl Benzilate is a muscarinic antagonist . So Pilocarpine should work as an antidote. 5 mg three times a day. Titrate upwards, not to exceed 10 mg per dose, to a maximum of 30 mg per day.
Ventricular fibrillation, and supraventricular or ventricular tachycardia.