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No, a flu shot tricks your immune system to think you have the flu and it makes and sends antibodies to fight the infection, if you have an otherwise healthy immune system. The immune responses do not "decrease" your system's ability to protect you and actually may help you respond more quickly to the next antigen (causative organism).

A flu shot just introduces a "dead" or weakened flu virus to your system so it can work out how to make antibodies against that organism in advance of a real infection by a full-strength flu virus. The immune system in healthy individuals is ready and able to go to work to fight infections, and the more organisms it works against, the more patterns for antibodies there are in your immune system "memory". Some of the old patterns may match the new organism well enough to provide protection, or make it easier for your immune system to build slight variations in them to work on the new antigen. So, exposure to more organisms may actually help prime your immune system so it can respond more quickly to any "invasion".

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Q: Will the flu shot decrease your immune system even more?
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