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Doubtful. I was taking Wellbutrin for quite some time (while taking random UA's) and never had any issues. All though I have had rumors of false positves for cocaine, I don't believe that too be true at all; they have vastly different metabolites, even though the effects of wellbutrin have been described as weak cocaine. Also, even if it were to cause a false positive, when they send it in to the lab it will show up as bupropion and you will be in the clear.

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Q: Will the prescription drug Wellbutrin cause a positive result in a UA drug test?
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