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If your motherboard can support 533 Mhz then no, not at all.

If it only supports 400 mhz then yes

If your a guru and want to run 533 mhz then overclock...

But it think if you are running your ram at 533 as an upgrade, i think time for a new computer buddy :)

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13y ago
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Q: Will using Ram 533 Mhz vs ram 400 mhz hurt my computer?
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