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Paget's disease is a disorder that involves abnormal bone destruction and regrowth, which results in deformity.
Alternative NamesOsteitis deformans
Causes, incidence, and risk factorsThe cause of Paget's disease is unknown, although it might have to do with genes or a viral infection early in life.
The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand.
In people with Paget's disease, there is an abnormal breakdown of bone tissue, followed by abnormal bone formation. The new bone is bigger, but weakened and filled with new blood vessels.
The disease may only be in one or two areas of the skeleton, or throughout the body. It often involves bones of the:
- Arm
- Collar
- Leg
- Pelvis
- Spine
- Bone pain (may be severe and persistent)
- Bowing of the legs and other visible deformities
- Enlarged head
- Fracture
- Headache
- Hearing loss
- Joint pain or stiffness
- Neck pain
- Reduced height
- Skull deformities
- Warmth of skin over the affected bone
Note: Most patients have no symptoms.
Signs and testsTests that may indicate Paget's disease include:
- Bone scan
- Bone x-ray
- Elevated markers of bone breakdown (for instance, N-telopeptide)
- Elevated serum alkaline phosphatase
This disease may also affect the results of the following tests:
TreatmentNot all patients need treatment. For example, patients who have abnormal blood tests only may not need treatment.
People with Paget's disease who are commonly treated include:
- Patients with deformities
- Patients with no symptoms when certain bones (such as weight-bearing bones) are involved, especially if the bony changes are progressing quickly, to reduce the risk of fractures
- Patients with symptoms
Drug therapy helps prevent further bone breakdown. Currently, there are several classes of medications used to treat Paget's disease. These include:
- Bisphosphonates -- These drugs are the first-line treatment, and they help increase bone density. Types of bisphosphonates include:
- Alendronate (Fosamax)
- Etidronate (Didronel)
- Pamidronate (Aredia)
- Risedronate (Actonel)
- Tiludronate (Skelid)
- Zoledronic acid (Zometa)
- Calcitonin -- This hormone is involved in bone metabolism. Types include:
- Intranasal (Miacalcin)
- Subcutaneous (Calcimar)
- Plicamycin (Mithracin)
Analgesics or nonsteroidal anti-inflammatory medications (NSAIDs) may also be given for pain.
Localized Paget's disease needs no treatment, if there are no symptoms and no evidence of active disease. Orthopedic surgery may be needed to correct a deformity in severe cases.
Support GroupsFor additional support and resources, see the Paget Foundation.
Expectations (prognosis)Disease activity and symptoms can generally be controlled with current medications. A small percentage of patients may develop a cancer of the bone called osteosarcoma. Some patients will need joint replacement surgery.
Complications- Bone fractures
- Deafness
- Deformities
- Heart failure
- Paraplegia
- Spinal stenosis
Call for an appointment with your health care provider if you develop symptoms of Paget's disease.
ReferencesGoldman L, Ausiello D.Cecil Textbook of Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007.
What else can I help you with?
What is pagets?
Paget's Disease is a bone disease. it hurt people over 30 and 30
What did paul robeson die of?
bone disorder called pagets disease
Do you die from pagets disease?
Generally not.
What is Paget's disease of bone?
Paget's disease is a chronic bone condition. In bone affected by Paget's disease, the bone remodeling is disturbed and not made right. In result the bone is formed abnormal. Pagets dieses happens to adults because their bones are older. This happens to about 1 % of adults. Scientist have not found out what causes pagets dieses. The symprtoms are arthritis Paget's disease commonly causes no symptoms. But some people have abnormally large bones which pinch their nerves causing tingling and numbness. The way pagets is treated is with a pain reliving medicine.
What chemistry is going on when there is too much calcium in the body and a bone injury is present?
its most probably is hyperparathyroidism.other causes include sarcoidosis,vit.d intoxication,pagets disease.
Is pagets disease a type of cancer?
Paget's disease of bone is not a type of cancer; it is a chronic disorder that involves the abnormal breakdown and formation of bone tissue, leading to enlarged and weakened bones. However, Paget's disease can increase the risk of developing certain types of bone cancer, such as osteosarcoma, although this is rare. There is also a separate condition known as Paget's disease of the nipple, which is associated with breast cancer.
Pagets disease do you get it from your parent?
There is a genetic link, so yes, you can get it from your parents, but it really is not well understood.
What is pagets disease?
From MedicineNet.com: " Paget's disease is a chronic bone condition characterized by disorder of the normal bone remodeling process. Normal bone has a synchronized relationship of mechanisms that act to lay down new bone and take up old bone. This relationship (referred to as remodeling) is essential for maintaining the normal calcium levels in our blood. In bone affected by Paget's disease, the bone remodeling is disturbed and not synchronized. As a result, the bone that is formed is abnormal, enlarged, not as dense, brittle, and prone to breakage (fracture). Paget's disease affects older bone of adults. It's estimated that 1% of adults in the U.S. have Paget's disease. There is an extremely rare form of Paget's disease in children, referred to as juvenile Paget's disease. Paget's disease is also known as osteitis deformans." See related links below for the rest of the article.
How is pagets disease caused?
Paget's disease is caused by - 1) hereditary cause . 2) viral cause - like paramixovirus infection or measles virus infection
What is another name for pagets disease?
Another name for Pagetâ??s disease is ostetitis deformans. In general, there are no symptoms associated with Pagetâ??s disease. It is often detected when x-rays are performed for other reasons.
Does Roy Clark have a bone disease?
No he does not have a bone disease
What is a name for a bone disease that starts with a p?
· porotic hyperostosis (a bone disease)
