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Renal papillary necrosis is a disorder of the kidneys in which all or part renal papillae die. The renal papillae is the area where the openings of the collecting ducts enter the kidney.
Alternative NamesNecrosis - renal papillae; Renal medullary necrosis
Causes, incidence, and risk factorsRenal papillary necrosis is most commonly associated with analgesic nephropathy. However, a number of conditions can cause this condition, including:
- Diabetic nephropathy
- Kidney infection
- Kidney transplant rejection
- Urinary tract obstruction
- Sickle cell anemia
Sickle cell anemia is a common cause of renal papillary necrosis in children.
SymptomsNecrosis (tissue death) of the renal papillae may make the kidney unable to concentrate the urine. Symptoms may include:
- Back pain or flank pain
- Bloody urine
- Cloudy urine
- Dark, rust-colored, or brown urine
- Tissue in the urine
Additional symptoms that may be associated with this disease:
- Chills
- Incontinence
- Increased urinary frequency or urgency
- Painful urination
- Passing large amounts of urine
- Urinating frequently at night
- Urinary hesitancy
An examination may reveal tenderness when touching the body over the affected kidney. There may be a history of chronic or recurrent urinary tract infections. There may be signs of obstructive uropathy or renal failure.
A urinalysis may show dead tissue in the urine.
An IVP may show obstruction or tissue in the renal pelvis or ureter.
TreatmentThere is no specific treatment for renal papillary necrosis. Treatment depends on the underlying cause. For example, if analgesic nephropathy is suspected as the cause, your doctor will recommend that you stop using the suspected medications. This may allow healing over time.
Expectations (prognosis)How well a person does depends on the underlying condition. If the underlying disorder can be controlled, the condition may go away on its own. In some cases, persons with this condition develop kidney failure.
Complications- Acute kidney failure
- Chronic kidney failure
- Acute unilateral obstructive uropathy
- Chronic unilateral obstructive uropathy
- Acute bilateral obstructive uropathy
- Chronic bilateral obstructive uropathy
- Chronic or recurrent UTI
- Hyperkalemia
- Hypovolemia
- Metabolic acidosis
Call for an appointment with your health care provider if you have bloody urine. Also call if other symptoms of renal papillary necrosis develop, especially after taking over-the-counter pain medications.
PreventionControl of Diabetes or sickle cell anemia may reduce risk. Prevention of renal papillary necrosis from analgesic nephropathy includes careful moderation in the use of medications, including over-the-counter analgesics.
What else can I help you with?
What is the papillary duct and what do they empty in to?
Papillary ducts are narrow tubes in the kidney that merge to form the renal papilla. They empty urine into the renal calyces within the renal sinus.
Can papillary cell carcinoma spread to lungs?
The papillary type of renal cell carcinoma tends to spread to areas near the site of origin, but it is possible.
What forms the collecting ducts converge as they extend toward the calyces?
The collecting ducts converge to form larger ducts known as papillary ducts. These papillary ducts then empty urine into the renal calyces, which are part of the renal pelvis where urine collects before being drained into the ureters.
What is the cup like structure that is located in renal sinus that receives urine from openings of papillary ducts?
Minor calyces
What happens to tubular fluid once it leaves the papillary duct?
Once the tubular fluid leaves the papillary duct in the kidney, it enters the minor calyx, which then flows into the major calyx, renal pelvis, and finally the ureter to be transported to the bladder for storage and eventual elimination as urine.
What are the two major causes of ATN?
ATN Acute Tubular Necrosis The causes of acute renal failure (ARF) are conventionally and conveniently divided into 3 categories: prerenal, renal, and postrenal. Prerenal ARF involves an essentially normal kidney that is responding to hypoperfusion by decreasing the glomerular filtration rate (GFR). Renal, or intrinsic, ARF refers to a condition in which the pathology lies within the kidney itself. Postrenal failure is caused by an obstruction of the urinary tract. Acute tubular necrosis (ATN) is the most common cause of ARF in the renal category.
What are the functions of the papillary duct?
The papillary duct, also known as the duct of Bellini, is responsible for transporting urine from the collecting ducts in the renal pyramids to the minor calyces of the kidney. It plays a crucial role in the final concentration of urine by allowing for the reabsorption of water and solutes under the influence of hormones like antidiuretic hormone (ADH). Additionally, the papillary duct helps maintain the overall balance of electrolytes in the body.
From the collecting ducts urine drains into the?
papillary ducts to minor calyces, these join becoming major calyces, these unite to form the renal pelvis, then on to the ureters, urinary bladder, urethra, toilet
Trace the flow of filtrate and urine through the urinary system?
The flow of filtrate and urine through the urinary system can be traced as follows: Glomerulus----> Capsular space---> Proximal convoluted tubule---> descending loop of Henle----> ascending loop of Henle---> distal convoluted tubule---> Collecting duct----> papillary duct------> minor calyce----> major calyce----> renal pelvis-----> ureters-----> urinary bladder-----> external urethral orifice
What has the author Harold Leeming Sheehan written?
Harold Leeming Sheehan has written: 'Renal cortical necrosis and the kidney of concealed accidental haemorrhage' -- subject(s): Diseases, Haemorrhage, Uterine, Kidneys, Uterine Haemorrhage
Long term use of non-steroidal anti-inflammatory drugs causes what nephropathy?
Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can lead to analgesic nephropathy. This condition is characterized by chronic kidney damage due to the cumulative effects of NSAIDs, which can cause renal ischemia, interstitial nephritis, and papillary necrosis. It is especially prevalent in individuals with pre-existing kidney conditions or those who use high doses over extended periods. Monitoring kidney function is essential for those on long-term NSAID therapy.
What are the three main regions of the kidney in their correct sequence from outermost to innermost?
renal cortex > renal medulla > renal pelvis1.renal medulla>renal pelvis>renal cortex2.renal medulla>renal cortex>renal pelvis3.renal cortex>renal medulla>renal pelvis4.renal cortex>renal pelvis>renal medulla
