Renin is a protein (enzyme) released by special kidney cells when you have decreased salt (sodium levels) or low blood volume.
Renin also plays a role in the release of aldosterone, a hormone that helps control the body's salt and water balance.
A test can be done to measure the amount of renin in your blood.
Alternative NamesPlasma renin activity; Random plasma renin; PRA
How the test is performedBlood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
How to prepare for the testYour health care provider may tell you to temporarily stop taking certain drugs that can affect test results.
Drugs that can affect renin measurements include:
You should eat a normal, balanced diet with low-sodium content (about 3 gm/day) for 3 days before the test.
How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedThis test is done as part of the diagnosis and treatment of high blood pressure.
If you have essential hypertension, your doctor may order a renin and aldosterone test to see if you sensitive to salt (which causes low renin with normal aldosterone levels). The test results help to guide your doctor in choosing the correct medication. Salt-sensitive patients with high blood pressure associated with low renin levels respond well to diuretic medications.
Normal ValuesNormal values range from 1.9 to 3.7 ng/mL/hour.
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results meanHigher than normal levels may indicate:
Lower than normal levels may indicate:
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
Renin measurements are affected by salt intake, pregnancy, time of day, and body position.
ReferencesVictor RG. Arterial hypertension. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 66.
Renin is a protein (enzyme) released by special kidney cells when you have decreased salt (sodium levels) or low blood volume.
Renin also plays a role in the release of aldosterone, a hormone that helps control the body's salt and water balance.
This article discusses the test to measure the activity of renin in your blood.
Alternative NamesPlasma renin activity; Random plasma renin; PRA
How the test is performedA blood sample is needed. For information on how this is done, see: Venipuncture
How to prepare for the testYour health care provider may tell you to temporarily stop taking certain drugs that can affect test results.
Drugs that can affect renin measurements include:
You should eat a normal, balanced diet with moderate sodium content (about 3 gm/day) for 3 days before the test.
How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedThis test is done as part of the diagnosis and treatment of high blood pressure.
If you have essential hypertension, your doctor may order a renin and aldosterone test to see if you are sensitive to salt (which causes low renin with normal aldosterone levels).
The test results may help to guide your doctor in choosing the correct medication. Salt-sensitive patients with high blood pressure associated with low renin levels respond well to diuretic medications.
Normal ValuesNormal values range from 0.2 to 3.3 ng/mL/hour.
The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
What abnormal results meanHigh levels of renin may be due to:
Low renin levels may be due to:
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
Renin measurements are affected by salt intake, pregnancy, time of day, and body position.
ReferencesVictor RG. Arterial hypertension. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 67.
Reviewed ByReview Date: 08/21/2011
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
renin
Renin is synthesized in the juxtaglomerular cells of the Kidney. Renin acts on the liver to synthesize Angiotensin I
Renin.
renin activates angiotensin in the blood
Renin is a protein released by cells in your kidneys when you have low sodium levels. Renin increases the amount of angiotensinogenase increasing blood pressure and renin inhibitors are used to prevent increased blood pressure that can lead to a number of problems.
The renin stimulation test is performed to help diagnose and distinguish the two forms of hyperaldosteronism.
Hypertension (high blood pressure) occurs in cases of excess renin.
by function is enzyme ... by structure is hormone
renin
Heart & brain functions effects blood pressure.
Plasma renin activity (PRA), also called plasma renin assay, may be used to screen for high blood pressure (hypertension ) of kidney origin, and may help plan treatment of essential hypertension
No. Renin causes the blood pressure to rise. By low blood pressure the body releases Renin from the kidneys. Renin cleaves an inactive peptide, called Angiotensinogen, converting it to Angiotensin I. Angiotensin I is then converted to Angiotensin II by ACE (Angiotensin-Converting-Enzyme). Angiotensin II causes vasoconstriction and thus an increase in blood pressure.