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Many of the most important states would not ratify the United States Constitution until the Bill of Rights was written. They were not happy with the original form of the Constitution.

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Q: What is a major factor leading to the ratification of the constitution?
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A major argument against ratification of the constitution was the absence of?

The major argument was the absence of a bill of rights in the Constitution

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The federalists and the democratic-republicans were the two major political parties after the ratification of the constitution.

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Which of what? I can't answer your question if it's vague like this.