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The three great explorers of the American West during Thomas Jefferson's administration were Meriwether Lewis, William Clark, and Zebulon Pike. Lewis and Clark led the famous Lewis and Clark Expedition (1804-1806) to explore the newly acquired Louisiana Territory and find a route to the Pacific Ocean. Zebulon Pike conducted his own explorations in the early 1800s, including the exploration of the southern portions of the Louisiana Territory and the Rocky Mountains, which contributed to the understanding of the American West. Their expeditions provided valuable information about the geography, resources, and Native American tribes of the region.

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