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Cigarette smoking leads to Heart disease. It contains numerous toxic agents along with nicotine. Nicotine stimulates the nicotinic receptors present in brain and in autonomous nervous system. So it excites the brain and both the sympathetic and parasympathetic nervous systems. It increases the blood pressure and make the wall of artery less elastic, so it hastens the process of atherosclerosis. Both of these are risk factors associated with myocardial infarction (heart attack).

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