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To replace the EGR valve in a 2001 Lexus RX300, first, disconnect the negative battery cable and remove any components obstructing access to the EGR valve. Disconnect the electrical connector and vacuum lines from the valve, then unbolt it from the intake manifold. Install the new EGR valve, reattach the vacuum lines and electrical connector, and finally, reconnect the battery cable before starting the engine to check for proper operation. Always ensure to clear any diagnostic trouble codes if applicable.

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