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528 miles taking this route:

  1. Take I-65 NORTH from Nashville to I-69 NORTH to FT. WAYNE via I-465 EAST (and later NORTH) around Indianapolis. (EXIT 106 off I-65 in Indiana to get onto I-465, follow signs to I-465 EAST; EXIT 37 off I-465 to get onto I-69 NORTH.)
  2. Take I-65 NORTH to I-94 to DETROIT and Chicago at EXIT 38 in Michigan. Follow signs to I-94 WEST to CHICAGO.
  3. Take I-94 WEST to Kalamazoo.
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