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Yes. Damage to the thalamus can lead to a loss of consciousness; bilateral damage leads to coma or more likely, death.

Damage to the pons and midbrain (parts of the brainstem) can also lead to loss of consciousness - rotational head injuries lead to rotation of the brain stem and axonal shearing (tearing of the long axons running through the brain stem supporting all the crucial arousal systems). This is why certain types of head injury can cause loss of consciousness.

Evidence from the use of anesthetics has shown reduced thalamic function suggesting the thalamus plays a crucial role in consciousness (Bogen, 1997; Fiske, 1999; Byas-Smith, 2002).

Thalmic activity is also reduced during sleep, when we are less 'alert' and arguably less 'conscious' than when awake (Braun, 1997; Maquet (2002).

So, consciousness is thought to be primarily linked to the thalamus (subcortical) rather than higher brain structures (cortical). This is supported by individuals born without a cortex (congenital decorticate), who still show signs of conscious behaviour.

NB the distinction between awareness and consciousness is not clear cut.

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Q: Can damage to the thalamus impair consciousness and sleep-wake cycles?
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