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In general terms we can say that for every molecule of glucose 38 molecules of ATP are formed. Here is how it works: The 12 electron pairs involved in glucose oxidation are not transferred directly to O2. Rather, they are transferred to the coenzymes NAD+ and FAD to form 10 NADH + 2 FADH2 in the reactions catalyzed by the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase, pyruvate dehydrogenase, and the citric acid cycle enzymes isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinate dehydrogenase, and the malate dehydrogenase. The electrons then pass into the electron transport chain where, through reoxidation of NADH and FADH2, they participate in the sequential oxidation-reduction of per 10 redox centers before reducing O2 to H2O. In this process, protons are expelled from the mitochondrion. The free energy stored in the resulting pH gradient drives the synthesis of ATP form ADP and Pi through oxidative phosphorylation. Reoxidation of each NADH results in the synthesis of 3 ATPs, and reoxidation of FADH2 yields 2 ATPs for a total of 38 ATPs for each glucose completely oxidized to CO2 and H2O (including the 2 ATPs made in glycolysis and the 2 ATPs made in the citric acid cycle).

The stoichiometric analysis can be expressed as:

C6H12O6 + 38ADP + 38Pi + 6O2 - 6CO2 + 44H2O + 38ATP


Moreover, the net gain of a single molecule of glucose can be analyzed as follows:


  1. Glucolysis produces directly 2 NADH, 4 ATPs, and 2 ATPs are consumed, giving a yield of 8 ATPs.
  2. Pyruvate oxydation produces 2 NADH to yield 6 ATPs.
  3. Acetyl-CoA oxydation (citric acid cycle) produces 6 NADH to yield 18 ATPs, 2 FADH2 to yield 4 ATPs, 2 ATPs or 2 GTPs formed directly, within the citric acid cycle, to yield 2 ATPs.

Therefore, the total yield per molecule of glucose is 38.


Finally, we have to consider that the final yield of ATP from glucose can be 36 instead of 38 because the number depends upon on which shuttle system is used to transfer reducing equivalents (2 NADH formed in cytosol during glycolisis) into the mitochondrial matrix.

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