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Proteins leave to rough endoplasmic reticulum via vesicles that bud off and enter into the Golgi apparatus. Here the proteins undergo further production and some are given cell surface receptors. They then exit the Golgi apparatus via a budding vesicle. That vesicle travels along the microtubules to the plasma membrane, where the vesicle fuses with the plasma membrane. some stay in the membrane as integral proteins and some are released into the area outside of the cell.

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βˆ™ 14y ago
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βˆ™ 12y ago

From the time the protein is made by rough ER, it is topologically "outside" the cell, first in the ER interior, then within the Golgi and transport vesicles, and finally outside the plasma membrane as the vesicles release their contents by exocytosis.

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Q: How can a protein secreting cell synthesize ans secrete its product without the protein ever having to cross a membrane?
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