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The receptors for ACh are non selective ligand-gated channels that once are bound by ACh allow Na and K to flow through...this depolarizes the membrane and cause VOLTAGE gated sodium channels to open and cause an action potential
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∙ 13y ago
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∙ 9y agoAcetylcholine functions as a neurotransmitter in many organisms, including humans. As a part of the peripheral nervous system, it binds to acetylcholine receptors that are found on skeletal muscle fibers.
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∙ 6y agoAcetylcholine has an ester functional group along with a quaternary nitrogen with a positive charge. The oxygen of the ester group can form a hydrogen bond with the serine of the receptor. The nitrogen is also electrostatically attracted to the receptor's anionic site. In addition, acetylcholine consists of methyl groups which may fit into the enzyme's hydrophobic spaces.
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∙ 6y agoAcetylcholine contains an ester functional group and a quaternary nitrogen with a positive charge. Meanwhile, the active site of the acetylcholinesterase has a serine residue and an anionic site. The ester functional group can hence form a hydrogen bond with the serine residue and the quaternary nitrogen can be electrostatically attracted to the anionic site. In addition, Acetylcholine may also contain methyl groups which fit into the enzyme's hydrophobic spaces. Acetylcholine can hence inhibit acetylcholinesterase in a reversible manner.
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∙ 11y agoReceptors in the muscle fiber membrane
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Acetylcholine in the synaptic cleft is broken down by?
choline esterase enzyme and there is 2 types of choline esterase 1 .truecholine esterase 2. pseudo choline esterase
What do Muscarinic receptors bind?
Acetylcholine.
What agent blocks enzymes resulting in a cholinergic crisis?
There are many. The enzymes that can be affected are choline acetyltransferase (for making acetylcholine), and acetylcholinesterase (for breaking down acetylcholine). The most commonly used enzyme inhibitors affecting the cholinergic system are the acetylcholinesterase inhibitors, such as physostigmine, or neostigmine, etc.
Which neuro transmitter released from ganglionic of the parasympathetic division?
Nor-adrenaline is secreted at post ganglionic sympathetic synapses. There is re-uptake of Nor-adrenaline by nerve ending and only partially destroyed there by the enzyme C.O.M.T. There is no enzyme like acetylcholinesterase present there as in post ganglionic parasympathetic synapse to destroy the acetylcholine.
What does an axon release when an impulse reaches the end of it?
Neurotransmitters to the synapse and the neurotransmitters bind with the receptors releasing the second messengers.
What prevents acetylcholine from accumulating in the neuromuscular junction?
The presence of an enzyme called acetylcholinesterasethat degrades acetylcholine is what prevents an accumulation of the neurotransmitter and sustained muscle contraction. Acetylcholinesterase is an enzyme that can be found within the neuromuscular junction. Thus, when a nerve impulse causes the release of acetylcholine at the neuromuscular junction, there is a critical time in which the neurotransmitter can bind to receptors on the muscle before it is degraded.
What breaks down acetylcholine?
Acetylcholinesterase
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine is degraded by acetylcholinesterase
What kind of enzyme breaks down acetylcholine?
Acetylcholinesterase
What is responsible for degrading acetylcholine so that it does not remain in the synapse?
acetylcholinesterase
Acetylcholine in the synaptic cleft is broken down by?
choline esterase enzyme and there is 2 types of choline esterase 1 .truecholine esterase 2. pseudo choline esterase
What do Muscarinic receptors bind?
Acetylcholine.
How do nerve agents produce in the body?
they inhibit the enzyme Acetylcholinesterase (AChE) allowing Acetylcholine (ACh) to accumulate.
Cleans up chemicals released by nerve cells?
AchE Acetylcholinesterase. It cleans up Ach Acetylcholine
What neurotransmitter does not go through the re-uptake process?
Acetylcholine is a neurotransmitter that does not go through the reuptake process. Instead, it is broken down by an enzyme called acetylcholinesterase in the synaptic cleft.
Help to counteract nerve agent poisoning?
Nerve agents are acetylcholinesterase inhibitors. Acetylcholinesterase is an enzyme that breaks down acetylcholine at nerve synapses. The antidote to counteract the nerve agent is an anticholinergic drug, such as atropine.
How is the neurotransmitter acetylcholine inactivated at the parasympathetic terminal receptor site?
Acetylcholine is primarily inactivated at the parasympathetic terminal receptor site by the enzyme acetylcholinesterase. Acetylcholinesterase breaks down acetylcholine into choline and acetate, which are then taken back up by the presynaptic terminal for further use in neurotransmitter synthesis. This inactivation process allows for the rapid termination of acetylcholine signaling and helps maintain proper neurotransmitter balance in the synapse.
