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Urea which is protein substrate
Excess nitrogen is converted into urea by the liver through a process called the urea cycle. Urea is then excreted in urine by the kidneys to maintain nitrogen balance in the body.
The enzyme responsible for metabolizing urea is urease. Urease breaks down urea into ammonia and carbon dioxide.
Urea is made in the body by the liver, it is a by product produced in the process of removing ammonia, Ammonia is extremely toxic for the human body. Urea is then excreted from the blood filtered through the kidneys.
The urea cycle takes place in the liver.
The breakdown of amino acids, specifically arginine and ornithine, in the liver results in the formation of urea. This process is known as the urea cycle or ornithine cycle, and it plays a key role in removing toxic ammonia from the body.
Urea is added when precipitating calcium oxalate to increase the solubility of the calcium oxalate crystals. This helps to prevent the formation of large, dense crystals that can be difficult to filter and wash. By adding urea, smaller and more easily filterable crystals are formed.
The trace mineral zinc acts as a cofactor in the formation of urea. It plays a crucial role in the activity of the enzyme urease, which catalyzes the hydrolysis of urea into ammonia and carbon dioxide. This process is essential for nitrogen metabolism and detoxification in the body.
Yes, urea formation is a result of the catabolism of amino acids. During amino acid breakdown, excess nitrogen is produced, which is converted into urea in the liver through the urea cycle. This process helps to eliminate nitrogen waste from the body in a non-toxic form, allowing for safe excretion via urine.
Urea can turn yellow due to the degradation of urea into ammonia and biuret under certain conditions, such as exposure to high temperatures or alkaline environments. This process can result in the formation of colored compounds, which can give the urea a yellow hue.
The formation of urea in the liver occurs through the urea cycle, primarily involving several key enzymes. These include carbamoyl phosphate synthetase I, which initiates the cycle by converting ammonia and bicarbonate into carbamoyl phosphate, followed by ornithine transcarbamylase, argininosuccinate synthetase, and argininosuccinate lyase. Finally, arginase catalyzes the conversion of arginine to urea and ornithine, completing the cycle.
Over all reaction of Urea Cycle. NH4 + CO2 + Aspartate + 3 ATP ---> Urea + Fumarate + 2 ADP + 2 Pi + AMP + PPi Formula is formed.
The stability of aqueous urea is affected by pH because urea can undergo hydrolysis in alkaline conditions, leading to the formation of ammonia and carbon dioxide. In acidic conditions, urea is more stable due to lower hydrolysis rates. Therefore, maintaining a neutral pH is important for the stability of aqueous urea solutions.
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Excess amino acids are broken down into urea primarily through the process of deamination, which occurs in the liver. During deamination, the amino group is removed from the amino acids, resulting in the formation of ammonia, which is then converted into urea through the urea cycle. This urea is subsequently excreted from the body via the kidneys in urine.
Approximately 50-60% of urea is filtered and recycled through the kidneys during the process of urine formation. The rest is excreted out of the body in urine.