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Precipitation of the salt calcium phosphate among fibers of the protein type I collagen.

This results from raising the concentrations of calcium ions and phosphate ions beyond

their "solubility product" concentration. This occurs next to special cells called osteocytes, and not inside their cytoplasm. Nobody has discovered the mechanism

by which osteocytes pump high concentrations of calcium ions and also high concentrations of phosphate ions into the same locations. One theory is that a special

protein ("osteoid") binds to both calcium ions and phosphate ions, so that they precipitate at concentrations that would not be high enough to cause precipitation if no osteoid were present.

If you know how osteocytes cause bone synthesis, then you should publish this information in a refereed journal, such as Nature.

akharris@bio.unc.edu

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